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7234 Mother Darvesh's welcome

BSc, PhD (University of New Brunswick)

Office:  Evaristus C213 (inside C212)
Lab: Evaristus C212

Phone: 457-6544

Research Interests:

Quantum chemistry, structure-activity relationships, Chemical Education 


Selected Recent Research Publications:

Darvesh, K. V. “Exploring the Clapeyron equation and the Phase Rule using Etch a Sketchtm.”  J. Chem. Ed., 2013, 90, 1472-1475.

DOI: 10.1021/ed300642v

Darvesh, K.V.; Pottie, I.R.; McDonald, R.S.; Martin, E.; Darvesh, S. "Targetting butyrylcholinesterase for Alzheimer’s disease therapy." In Quantuum Biochemistry Matta, Cherif, ed.; Wiley-VCH, Germany, 2010, Vol. 2, pp 757-780. 
DOI: 10.1002/9783527629213.ch28

Darvesh, S.; Pottie, I.R.; Darvesh, K.V.; McDonald, R.S.; Walsh, R.; Conrad, S.; Penwell, A.; Mataija, D.; Martin, E. "Differential binding of phenothiazine urea derivatives to wild-type human cholinesterases and butyrylcholinesterase mutants" Bioorg. Med. Chem., 2010, 18, 2232-2244.
DOI: 10.1016/j.bmc.2010.01.066

Darvesh, S.; Darvesh, K.V.; McDonald, R.S.; Mataija, D.; Walsh, R.; Mothana, S.; Lockridge, O.; Martin E. “Carbamates with Differential Mechanism of Inhibition Toward Acetylcholinesterase and Butyrylcholinesterase,” J. Med. Chem., 2008, 51, 4200-4212.
DOI: 10.1021/jm8002075

Darvesh, S.; Darvesh, K.V.;  Mataija, D.; Conrad, S.; Gomez, G.; Walsh, R.; Martin, E. "Selective reversible inhibition of human butyrylcholinesterase by aryl amide derivatives of phenothiazine,"  Bioorg. Med. Chem., 200715, 6367-6378.
DOI: 10.1016/j.bmc.2007.06.060

Darvesh, S.; McDonald, R.S.; Darvesh, K.V.; Mataija, D.; Mothana, S.; Cook, H.; Carneiro, K.M.; Richard, N.; Walsh, R.; Martin, E. “On the active site for hydrolysis of aryl amides and choline esters by human cholinesterases,” Bioorg. Med. Chem. 2006, 14, 4586-4599.
DOI: 10.1016/j.bmc.2006.02.021

Potvin, M.; Mothana, B.; Albrecht, L.; Valenta Darvesh, K.; Langler, R.F.  “The Role of Ylides in the Chlorination of Unsymmetrical Sulfides:  An Ab Initio Molecular Orbital Study,” Aust. J. Chem., 2005, 58, 143-148.
DOI: 10.1071/CH03219

Darvesh, S.; McDonald, R.; Penwell, A.; Conrad, S.; Valenta Darvesh, K.; Mataija, D.; Gomez, G.; Caines, A.; Walsh, R.; Martin, E. “Structure-activity relationships for inhibition of human cholinesterases by alkyl amide phenothiazine derivatives,” Bioorg. Med. Chem., 200513, 211-222.
DOI: 10.1016/j.bmc.2004.09.059