BSc, PhD (University of New Brunswick)
Office: Evaristus C213 (inside C212)
Lab: Evaristus C212
Phone: 457-6544
msvu.ca
Research Interests:
Quantum chemistry, structure-activity relationships
Selected Recent Research Publications:
Darvesh, K.V.; Pottie, I.R.; McDonald, R.S.; Martin, E.; Darvesh, S. "Targetting butyrylcholinesterase for Alzheimer’s disease therapy." In Quantuum Biochemistry Matta, Cherif, ed.; Wiley-VCH, Germany, 2010, Vol. 2, pp 757-780.
DOI: 10.1002/9783527629213.ch28
Darvesh, S.; Pottie, I.R.; Darvesh, K.V.; McDonald, R.S.; Walsh, R.; Conrad, S.; Penwell, A.; Mataija, D.; Martin, E. "Differential binding of phenothiazine urea derivatives to wild-type human cholinesterases and butyrylcholinesterase mutants" Bioorg. Med. Chem., 2010, 18, 2232-2244.
DOI: 10.1016/j.bmc.2010.01.066
Darvesh, S.; Darvesh, K.V.; McDonald, R.S.; Mataija, D.; Walsh, R.; Mothana, S.; Lockridge, O.; Martin E. “Carbamates with Differential Mechanism of Inhibition Toward Acetylcholinesterase and Butyrylcholinesterase,” J. Med. Chem., 2008, 51, 4200-4212.
DOI: 10.1021/jm8002075
Darvesh, S.; Darvesh, K.V.; Mataija, D.; Conrad, S.; Gomez, G.; Walsh, R.; Martin, E. "Selective reversible inhibition of human butyrylcholinesterase by aryl amide derivatives of phenothiazine," Bioorg. Med. Chem., 2007, 15, 6367-6378.
DOI: 10.1016/j.bmc.2007.06.060
Darvesh, S.; McDonald, R.S.; Darvesh, K.V.; Mataija, D.; Mothana, S.; Cook, H.; Carneiro, K.M.; Richard, N.; Walsh, R.; Martin, E. “On the active site for hydrolysis of aryl amides and choline esters by human cholinesterases,” Bioorg. Med. Chem. 2006, 14, 4586-4599.
DOI: 10.1016/j.bmc.2006.02.021
Potvin, M.; Mothana, B.; Albrecht, L.; Valenta Darvesh, K.; Langler, R.F. “The Role of Ylides in the Chlorination of Unsymmetrical Sulfides: An Ab Initio Molecular Orbital Study,” Aust. J. Chem., 2005, 58, 143-148.
DOI: 10.1071/CH03219
Darvesh, S.; McDonald, R.; Penwell, A.; Conrad, S.; Valenta Darvesh, K.; Mataija, D.; Gomez, G.; Caines, A.; Walsh, R.; Martin, E. “Structure-activity relationships for inhibition of human cholinesterases by alkyl amide phenothiazine derivatives,” Bioorg. Med. Chem., 2005, 13, 211-222.
DOI: 10.1016/j.bmc.2004.09.059
Mothana, B.; Bourgeois, T.A.; Longley, R.M.; Devereaux, G.-L.; McDonald, R.S.; Valenta Darvesh, K. "Geometry and energy of amidoenetholate conformers formed by ring-opening of several thiazolium ions in base: a theoretical study using density functional theory", Arkivoc, 2001, 2, 116-133. (Download here>>).
Frederiksen, M.U.; Langler, R.F.; Watson, K.J.; Penwell, A.; Valenta Darvesh, K. "Are Polarized cyclobutadienes non-aromatic?" Aust. J. Chem., 2000, 53, 443-450.
Ginsburg, J.L.; Darvesh, K.V.; Axworthy, P.; Langler, R.F. "An ab initio molecular orbital study of sulfur-substituted carbanions: toward an understanding of regiochemistry in the chlorination of unsymmetrical sulfides," Aust. J. Chem., 1997, 50, 517-521.
Burford, N.; Clyburne, J.A.C.; Silvert, D.; Warner, S.; Alex Whitla, W.; Valenta Darvesh, K. "Nitrogen-phosphorus multiple bond vibration assignments in the infrared and Raman," Inorg. Chem., 1997, 36, 482-484.
DOI: 10.1021/IC960133E